Structural formula of (−)-β-caryophyllene · C₁₅H₂₄.
β-Caryophyllene
Peppery, woody, spicy
β-Caryophyllene is a sesquiterpene found in many medical cannabis strains. Aroma: peppery, woody, spicy. In Tier-A literature it is most strongly associated with relaxation and mood. terpen.cloud lists every currently available pharmacy strain high in β-caryophyllene.
Effect profile
β-Caryophyllene in the cannabis context
β-Caryophyllene is the most pharmacologically remarkable terpene of all: it binds directly to the body's own CB2 receptor, which formally makes it a phytocannabinoid. That mechanism explains its broad effect profile and makes caryophyllene the second key active compound alongside the classic cannabinoids THC and CBD. It is also found in black pepper, cloves and hops.
At 1.5 each, caryophyllene is anxiety-easing, mood-lifting, pain-relieving and anti-inflammatory. Sleep, focus and activation are not part of its profile. It is a broadly active terpene with a clear emphasis on physical and emotional balance.
In cannabis, caryophyllene is the second most common terpene and defines strains like Girl Scout Cookies, Original Glue, Chemdawg and Bubba Kush. You recognize it by the peppery, spicy, faintly woody aroma. High caryophyllene levels signal a balanced effect profile centered on pain and inflammation.
Pharmacological notes: CB2 activity (A1), a selective CB2 receptor agonist with a repeatedly confirmed mechanism of action.