Structural formula of (R)-(+)-limonene · C₁₀H₁₆.
Limonene
Citrus, orange, fresh
Limonene is a monoterpene found in many medical cannabis strains. Aroma: citrus, orange, fresh. In Tier-A literature it is most strongly associated with relaxation and mood. terpen.cloud lists every currently available pharmacy strain high in limonene.
Effect profile
Limonene in the cannabis context
Limonene is the citrus terpene and a versatile modulator of mood and anxiety. Its relaxation score of 2.5 rests on Spindle et al. 2024 (PMID 38498958): vaporized D-limonene selectively blunted THC-induced anxiety. Limonene is found in citrus peel, juniper and peppermint.
Limonene lifts mood and reduces inflammation, each at a score of 1.5. Sleep, focus and activation are not its territory. It is the terpene for emotional grounding without a sedative effect.
In cannabis, limonene defines sativa-leaning classics like Super Lemon Haze, Tangie, Durban Poison and Jack Herer. You recognize it by the fresh, orange-citrusy aroma. High limonene levels signal an anxiety-easing, mood-lifting effect profile with a bright note.
Pharmacological notes: Oncological signaling pathways, documented in a breast cancer pilot trial.